Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites


Antibiotics resistance is occurring due to use of antibiotics in prevention of microbial infections without previous antibiogram together with treatment noncompliance and routine application in agricultural and aquaculture [1]. The World Health Organization (WHO) estimated that about 700,000 people die every year because antibiotics have become ineffective against common pathogens, and that 10 million lives per year will be at risk by 2050 [2]. Research must be promoted to find novel classes of antibiotics with new action mechanisms. Carvacrol (2-methyl-5-isopropylphenol), a phenolic monoterpene abundant in essential oils of aromatic plants especially of Labiatae family (Origanum, Satureja, and Thymus), has shown antibacterial, antifungal, and antiviral properties against resistant pathogens [3,4]. The mechanism of action of carvacrol against microorganisms is associated with the presence of a hydroxyl group and an aromatic ring.



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